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CHIRAL SEPARATION, CAPILLARY ELECTROPHORESIS: SEPARATION OF CHLOROQUINE AND ITS ENANTIOMERS IN PHARMACEUTICALS USING CAPILLARY ELECTROPHORESIS TECHNIQUE ePub download

by KHALDUN AL AZZAM

  • Author: KHALDUN AL AZZAM
  • ISBN: 3639210727
  • ISBN13: 978-3639210729
  • ePub: 1762 kb | FB2: 1533 kb
  • Language: English
  • Category: Chemistry
  • Publisher: VDM Verlag Dr. Müller (November 19, 2009)
  • Pages: 96
  • Rating: 4.1/5
  • Votes: 411
  • Format: rtf docx lit rtf
CHIRAL SEPARATION, CAPILLARY ELECTROPHORESIS: SEPARATION OF CHLOROQUINE AND ITS ENANTIOMERS IN PHARMACEUTICALS USING CAPILLARY ELECTROPHORESIS TECHNIQUE ePub download

Fast development of the practice and theory of chiral CE occurred in the past 30 years and today one can consider this technology to have a solid and mature theoretical background.

Fast development of the practice and theory of chiral CE occurred in the past 30 years and today one can consider this technology to have a solid and mature theoretical background enantioseparations by using CE but also to present the authors personal view where shall we head to with.

Using electrospray-mass spectrometry (ESI–MS) it was revealed that OFL forms an inclusion complex with HPβCD at 1:1 stoichiometry. The interaction of the enantiomers with the host was further investigated by molecular modeling using molecular mechanics dockings, PM7 semiempirical calculations and molecular dynamics simulations.

The proposed method was applied to chiral separation of Bup enantiomers in rabbit serum and pharmaceutical injections.

The influences of the concentration and pH of borate buffer solution, beta-CD concentration and methanol content in the background electrolyte were investigated. The proposed method was applied to chiral separation of Bup enantiomers in rabbit serum and pharmaceutical injections.

Valenzuela et al. reported the CE separation of different sulfonium ions, and in a follow-up publication demonstrated the separation of the enantiomers of several sulfonium ions using both neutral and randomly sulfated b-CD. 0021-9673, 00, $ – see front matter  2000 Elsevier Science . PII: S0021-9673( 00 )00663-4 W. Zhu et a. J. Chromatogr. A 895 (2000) 247 – 254 248 The organophosphate triesters constitute one of the largest classes of agricultural insecticides used in the world today.

Springer Nature is developing a new tool to find and evaluate Protocols.

Bryant, in Encyclopedia of Separation Science, 2000. A separate technique employing narrow-bore tubes (10–200 μm . for high-efficiency resolution of both large and small molecules includes chiral components.

Chromatography, Liquid.

Chromatography, Liquid.

This is contributed to the advantages it offers when compared to chromatographic techniques: (1) low consumption of samples and solvents; (2) high separation efficiency and resolution; (3) versatility.

The chiral analysis of environmental pollutants is a fairly recent development and attracts scientists needing to investigate the toxicity of enantiomers. For example, approximately 250f agrochemicals are chiral in nature, including pesticides that are applied as their racemates in agricultural and forestry activities.

Currently, there is considerable interest in the synthesis and separation of enantiomeric compounds because of their importance in biochemistry, pharmaceutical, etc. Frequently the analytical methods used for the enantiomeric separations, for the monitoring the progress of asymmetric synthesis or establishing the optical purity of the products are chromatography. More recently capillary electrophoresis (CE) has been added to the list. CE is an interesting technique that shows promise for the resolution of enantiomers. This is accomplished by adding to the background electrolyte with suitable chiral selector that is capable of discriminating between the enantiomers. In this work, CE method was demonstrated for the separation of the enantiomers of chloroquine (CQ), a synthetic drug that is widely used as an anti-malarial agent. The application of the optimized CE method for the determination of CQ in pharmaceutical samples is presented. This book will be useful for chemists, pharmacists and scientists with interest in CE separation of enantiomers.
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