Genetic Variance Detection: Nuts Bolts of dHPLC in Genomics (Nuts Bolts Series) ePub download
by Karl Hecker PhD
- ISBN: 0966402774
- ISBN13: 978-0966402773
- ePub: 1513 kb | FB2: 1533 kb
- Language: English
- Category: Biological Sciences
- Publisher: Dna Press; 1 edition (July 26, 2003)
- Pages: 202
- Rating: 4.4/5
- Votes: 302
- Format: lrf txt rtf lit
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Hecker PhD, Karl Genetic Variance Detection: Nuts & Bolts of dHPLC in Genomics (Nuts & Bolts Series). ISBN 13: 9780966402773. Genetic Variance Detection: Nuts & Bolts of dHPLC in Genomics (Nuts & Bolts Series).
Variations in mammalian genomic sequences occur at an estimated frequency of at least one base per thousand .
Variations in mammalian genomic sequences occur at an estimated frequency of at least one base per thousand bases. SECTION I: FUNDAMENTALS OF DHPLC 1. Basics of automated, high-accuracy mutation screening with the WAVE Nucleic Acid Fragment Analysis Systems 2. Influence of PCR on DHPLC Polymorphism Characterization SECTION II: GENE SPECIFIC APPLICATIONS OF MUTATION DETECTION BY DHPLC 3. Denaturing High Performance Liquid Chromatography (DHPLC), and important mutation detection technique in mutation analysis of the breast and ovarian cancer predisposing.
This work explains the importance and applications of genetic variation detection, a highly sensitive and cost-effective technology used to explore the pivotal relationship of sequence variability and function. A select group of scientists who have adopted this new technology explain the fundamentals of genetic variation detection, as well as some of the innovative applications they have developed themselves.
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Genetic Variance Detection, Nuts and Bolts of DHPLC. DHPLC analysis proved advantageous for the detection of novel and multiple mutations. USA: Xela Schenk, DNA Press, 2003. 14. Anonymous (a). Helix Guidelines and Procedures.
Presentation on theme: "Nuts and Bolts of Clinical Genomic Sequencing . 11 Fusion Detection Hybrid Capture. 12 Tumor-Normal Contamination.
Presentation on theme: "Nuts and Bolts of Clinical Genomic Sequencing Thomas Stricker MD PhD Vanderbilt University. - Presentation transcript: 1 Nuts and Bolts of Clinical Genomic Sequencing Thomas Stricker MD PhD Vanderbilt University. 6 877 Lung Specimens (843 patients) 7/1/2010-2/28/2013 Data courtesy of Dr. William Pao and Dr. Mia Levy OncogeneFrequency (%) Treatment EGFR10-35Gefitinib, erlotinib, afatinib ALK fusion3-7Crizotinib MET amp2-4Crizotinib DDR2~4Dasatinib HER22-4Afatinib ROS1 fusion1Crizotinib BRAF Y472CrareDasatinib BRAF.