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From Protein Structure to Function with Bioinformatics ePub download

by Daniel John Rigden

  • Author: Daniel John Rigden
  • ISBN: 1402090579
  • ISBN13: 978-1402090578
  • ePub: 1892 kb | FB2: 1177 kb
  • Language: English
  • Category: Medicine & Health Sciences
  • Publisher: Springer; 2009 edition (February 13, 2009)
  • Pages: 328
  • Rating: 4.6/5
  • Votes: 430
  • Format: lrf docx azw lrf
From Protein Structure to Function with Bioinformatics ePub download

Proteins lie at the heart of almost all biological processes and have an incredibly wide range of activities. Central to the function of all proteins is their ability to adopt, stably or sometimes transiently, structures that allow for interaction with other molecules.

Proteins lie at the heart of almost all biological processes and have an incredibly wide range of activities. An understanding of the structure of a protein can therefore lead us to a much improved picture of its molecular function. This realisation has been a prime motivation of recent Structural Genomics projects, involving large-scale experimental determination of protein structures, often those of proteins about.

The axiom that structure determines function, and may therefore be used to predict function, lies at the heart of the structure prediction and structure-based function annotation areas covered in this book. Although it is the deluge of Structural Genomics outputs, many of unknown function, which has stimulated development of structure-based function prediction methods, all the methods can be applied, at least to some extent, to model structures. The first chapters of this book therefore cover generation and inference of structures for protein sequences.

This book is about protein structural bioinformatics and how it can help understand and predict protein function. From Protein Structure to Function with Bioinformatics. Comprehensively covers all recent developments in structure-based function prediction of proteins. Genuinely world class roster of authors. Includes full coverage of techniques to generate and infer model protein structures.

Central to the function of all proteins is their ability to adopt, stably or sometimes transiently, structures that allow for interaction with other molecules. An understanding of a protein's structure can therefore lead us to a much improved picture of its molecular function(s). This realisation has been a prime motivation of recent Structural Genomics projects, involving large-scale experimental determination of protein structures, often those of proteins about which little is known of function.

Автор: Daniel John Rigden Название: From Protein Structure to Function with Bioinformatics ISBN: 9048180589 . This book comprehensively covers all recent developments in structure-based function prediction of proteins.

Описание: Proteins lie at the heart of almost all biological processes. Автор: Daniel John Rigden (E. Daniel Rigden is a Reader in post-genomic bioinformatics in the Institute of Integrative Biology. It covers structure-based methods that can assign and explain protein function based on overall folds, characteristics of protein surfaces, occurrence of small 3D motifs, protein-protein interactions and on dynamic properties. His interests span the broad relationships between protein sequences, structures and functions and how these evolve with time. As such, he applies a wide range of bioinformatics tools to diverse proteins of interest.

Автор: Daniel J. Rigden Название: From Protein Structure to Function with Bioinformatics ISBN . Описание: This book is about protein structural bioinformatics and how it can help understand and predict protein function.

Описание: This book is about protein structural bioinformatics and how it can help understand and predict protein function.

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A detailed consideration of current structure-based function prediction methodologies forms the second part of this book, which concludes with two chapters, focusing specifically on case studies, designed to illustrate the real-world application of these methods.

Proteins lie at the heart of almost all biological processes and have an incredibly wide range of activities. Central to the function of all proteins is their ability to adopt, stably or sometimes transiently, structures that allow for interaction with other molecules. An understanding of the structure of a protein can therefore lead us to a much improved picture of its molecular function. This realisation has been a prime motivation of recent Structural Genomics projects, involving large-scale experimental determination of protein structures, often those of proteins about which little is known of function. These initiatives have, in turn, stimulated the massive development of novel methods for prediction of protein function from structure. Since model structures may also take advantage of new function prediction algorithms, the first part of the book deals with the various ways in which protein structures may be predicted or inferred, including specific treatment of membrane and intrinsically disordered proteins. A detailed consideration of current structure-based function prediction methodologies forms the second part of this book, which concludes with two chapters, focusing specifically on case studies, designed to illustrate the real-world application of these methods. With bang up-to-date texts from world experts, and abundant links to publicly available resources, this book will be invaluable to anyone who studies proteins and the endlessly fascinating relationship between their structure and function.